Particle physicists reason backwards. They do not find things, but kinds of things. It is analogous to if I would explore the world for the first time and then find jews, by finding a jew, blacks by finding a black, dogs by finding a dog and houses by finding a house. The problem with this backward reasoning is that classification is ultimately contradictory (as Bertrand Russell demonstrated in 1901) , and that this approach thus is endless. Never will the search of particle physicists thus end, simply because it is inconsistent.
The problem with particle physics is that it assumes that particles are real, because this assumption is contradictory. Particle physics is thus fundamentally contradictory.